Description
INTENDED USE
ELITech Clinical Systems GAMMA-GT SL is an in vitro diagnostic reagent intended for the quantitative determination of Gamma Glutamyl Transferase (g-GT) in human serum and plasma samples.
Gamma-glutamyl transpeptidase and isoenzymes measurements are used in the diagnosis and treatment of liver diseases such as alcoholic cirrhosis and primary and secondary liver tumors.
CLINICAL SIGNIFICANCE
Gamma-glutamyltransferase (g-GT) is a membrane bound enzyme mainly present in kidneys, pancreas, liver and
prostate. This enzyme plays a significant role in glutathione metabolism and takes part in the transport of amino acids into the cells.
The rise of g-GT activity, is more sensitive than Alkaline Phosphatase (ALP) during an affection of the liver or bile ducts. The highest increases are observed in cases of intrahepatic or posthepatic biliary obstructions (reaching levels from 5 to 30 times normal), primary or metastatic neoplasms of liver, prancreatic diseases (pancreatitis, cancer, …). Gamma-Glutamyltransferase (g-GT) is useful as a marker for pancreatic cancer, prostatic cancer and hepatoma because levels reflect remission and recurrence. More moderate elevations are observed during infectious hepatitis, cirrhosis and hepatic steatosis. Alcohol in chronic ingestion, some drugs like antiepileptic (phenobarbital, phenytoine) can also increase g-GT rate in the serum.
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