Hydroxylamine hydrochloride

Hydroxylamine hydrochloride (Hydroxylammonium chloride) participates in the synthesis of 1,2,4-oxadiazoles, secondary amides and tertiary amides.

Hydroxylamine hydrochloride (NH₂OH.HCl) is a hygroscopic salt widely used as a reactant in electrophilic substitution reactions, oxidation, and reduction reactions. It is also used in the synthesis of nitriles, pyrazoles, isoxazoles, nitrones, and pyridine.

Hydroxylamine hydrochloride can be used as a reactant:

• in the synthesis of primary amides from aldehydes in the presence of cesium carbonate (Cs₂CO₃) as a catalyst.
• in the conversion of alicyclic /aliphatic carbonyl compounds and the aromatic aldehydes into corresponding oximes.
• in the one-pot synthesis of nitriles from aldehydes in the presence of sodium sulfate (anhyd) and sodium bicarbonate catalysts.
• It can also be used as a reducing agent in the preparation of single-layer reduced graphene oxide (RGO) sheets and films.

MAO inhibitor; inhibits platelet aggregation.

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany