Description
General description
Iodine exhibits exceptionally high dielectric polarization in various solvents (dioxane, isobutylene, p-xylene and benzene).
Application
Catalyst for synthesis of esters by condensation of carboxylic acids with alcohols or transfesterification.
Iodine has been used for the easy visualization of 9-bromononanoic acid, allyl ester by thin layer chromatography (TLC). It has also been used for the preparation of oxidation solution, required for the synthesis of oligodeoxynucleotides bearing 3′-terminal phosphorothioate.
Iodine may be used to catalyze:
- Synthesis of 5-(4-nitrophenyl)-10,15,20-triphenylporphyrin.
- Oxidative C-H bond amination of saturated hydrocarbons.
- Protection of amines with benzyloxycarbonyl (Cbz) group.
- Direct oxidative coupling/annulation of β-keto esters or 2-pyridinyl-β-esters with alkenes to form dihydrofurans and indolizine, respectively.
- Thiocyanation of aromatic systems to form aryl thiocyanates.
- Esterification of cellulose with acetic anhydride to form cellulose triacetate.
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