L-α-Phosphatidylcholine, egg yolk, lyophilized powder

Phosphatidylcholine belongs to the class of glycerophoshpolipids and contains choline as the head-group. Choline is attached to the glycerol of fatty acids ester-bound to backbone. It is the major phospholipid found in eukaryotic organism.

L-α-Phosphatidylcholine has been used:

• to form a thin lipid film used in Kupffer cell depletion by liposome-encapsulated clodronate
• as a component of assay buffer used in γ-secretase in vitro assay
• in the preparation of substrate mix for its use in HPLC (high performance liquid chromatography) assay of 5-lipoxygenase enzyme activity

It also acts as a source of lipid messengers/ bioactive lipids including: lysophosphatidylcholine, diacylglycerol, phosphatidic acid, lysophosphatidylcholine, arachidonic acid and platelet activating factor. Phosphatidylcholine is produced in the liver by the CDP-choline (cytidine diphosphocholine) pathway.

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.

Packaged under Argon

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).