N,N-Dimethylformamide ACS reagent, ≥99.8% [2.5 Litres]

N, N-Dimethylformamide (DMF) is an organic compound commonly used as a reagent as well as a solvent in organic synthesis. It plays multiple roles in various reactions such as formylating agent, dehydrating agent, reducing agent as well as a catalyst.

DMF can be used as:

• A formylating agent for organometallic compounds.
• A reactant to prepare Vilsmeier reagent by reacting with phosphorus oxychloride.
• A reagent for amination of aryl chlorides in the presence of potassium t-butoxide.
• A reducing agent for metal salts to prepare metal colloids.
• A catalyst for the regioselective silylation of unprotected carbohydrates.

DMF can also be used in the following:

• DMF-Phosgene catalytic system is used to prepare alkyl halides from alcohols.
• DMF-POCl₃ is used to convert acyclic and cyclic enolizable ketones to β-chloro-α, β-unsaturated aldehydes.
• DMF-POCl₃ is used to synthesize quinoline-3-carbaldehydes from acylanilides.
• DMF-SOCl₂ combination is used to dehydrate oximes to nitriles.
• DMF-Ag₂O converts α-bromopropionamides to oxazolidinones.
• DMF is frequently used as a solvent in many chemical reactions, which require a high solvency power.

Solvent for many hydrophobic organic compounds.