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Description
Application
Sodium fluoride has been used:
- as a source of fluoride ions, to analyse its impact on spermatogenesis and capacitation in vitro
- as an additive in the extraction buffer for the isolation of nuclei, cytoplasmic and nuclear proteins
- as a component of lysis buffer for the lysis of human ovarian adenocarcinoma OVCAR3 cells
Biochem/physiol Actions
Sodium fluoride (NaF) prevents dental caries, by catalysing the diffusion of calcium and phosphate and remineralizes the lesions. Fluoride affects spermatogenesis and capacitation process in the female reproductive tract. Fluoride induces oxidative stress, DNA damage in ovary ultimately affects the development of oocytes. Fluoride supplementation enhances bone mineral density. 18F-NaF is a radiotracer used in positron emission tomography (PET) to identify atherosclerotic lesions and other cardiac plaques.
PROPERTIES
grade
ACS reagent
Agency
reag. ISO
reag. Ph. Eur.
vapor pressure
1 hPa ( 1077 °C)
product line
EMSURE®
Assay
≥99.5% (precipitation titration)
form
crystals
potency
148.5 mg/kg LD50, oral (Rat)
impurities
≤0.01% In water insoluble matter
≤0.04% Free alkali (as NaOH)
≤0.05% Free acid (as hydrofloric acid)
loss
≤0.2% loss on drying, 150 °C, 4 h
pH
10.2 (20 °C, 40 g/L in H2O)
mp
996 °C
density
2.8 g/cm3 at 20 °C
anion traces
chloride (Cl–): ≤0.003%
hexafluorosilicate (SiF62-): ≤0.075%
sulfate (SO42-): ≤0.01%
sulfite (SO32-): ≤0.005%
cation traces
Ca: ≤0.004%
Cu: ≤0.0002%
Fe: ≤0.002%
K: ≤0.02%
excess alkali (as NaOH): ≤0.04%
heavy metals (as Pb): ≤0.001%
storage temp.
2-30°C
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