Description
Synonym(s): THF, Butylene oxide, Oxolane, Tetramethylene oxide
Empirical Formula (Hill Notation): C4H8O
General description
Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).
Application
Suitable for HPLC, spectrophotometry, environmental testing
Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer,[6] respectively.
PROPERTIES
vapor density
2.5 (vs air)
Pack Size
1 Litre
vapor pressure
114 mmHg ( 15 °C)
143 mmHg ( 20 °C)
Assay
≥99.9%
form
liquid
autoignition temp.
610 °F
expl. lim.
1.8-11.8 %
technique(s)
HPLC: suitable
impurities
≤0.0005% non-volatile matter
≤0.002% free acid (as CH3COOH)
≤0.05% peroxides (as H2O2)
≤0.05% water (Karl Fischer)
evapn. residue
≤0.0005%
color
APHA: ≤10
refractive index
n20/D 1.407 (lit.)
pH
~7
bp
65-67 °C (lit.)
mp
−108 °C (lit.)
density
0.889 g/mL at 25 °C (lit.)
absorption
≤0.0044 at 315 nm
≤0.005 at 350 nm
≤0.005 at 400 nm
≤0.02 at 300 nm
≤0.046 at 275 nm
≤0.18 at 250 nm
≤0.26 at 245 nm
≤1.0 at 212 nm
UV absorption
λ: 245 nm Amax: ≤0.26
λ: 275 nm Amax: ≤0.046
λ: 315 μm Amax: ≤0.0044
suitability
complies for IR spectroscopy
application(s)
food and beverages
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