Description
for synthesis
Synonyms: Zirconium(IV) chloride, Zirconium tetrachloride
Empirical Formula (Hill Notation): Cl4Zr
General description
Zirconium(IV) chloride is a Lewis acid catalyst, widely used in organic synthesis for the preparation of useful key intermediates. Since it is a stable and environmentally friendly catalyst used in various chemical reactions such as carbon-carbon bond formation reactions, reduction reactions, protection, and deprotection reactions.
Application
Zirconium(IV) chloride can be used as a catalyst to synthesize:
- β-amino alcohols by ring-opening of epoxides with aromatic amines.
- β-amino analogs via conjugate addition of aliphatic amines to α,β-unsaturated ester, nitriles, and ketones.
- 1,3,4-oxadiazole derivatives by cyclodehydration of 1,2-diacylhydrazines.
- 3,4-Dihydropyrimidinone derivatives via Biginelli condensation reaction of aromatic aldehyde, β-ketoester, and urea.
Analysis Note
Assay (argentometric): ≥ 98.0 %
Hafnium (Hf): ≤ 40 ppm
Identity (ICP-OES): passes test
Hafnium (Hf): ≤ 40 ppm
Identity (ICP-OES): passes test
PROPERTIES
vapor pressure
1.3 hPa ( 190 °C)
Pack Size
250 g
form
crystals
potency
1688 mg/kg LD50, oral (Rat)
pH
<1 (20 °C in H2O, saturated aqueous solution)
mp
437 °C
density
2.80 g/cm3 at 15 °C
bulk density
1200 kg/m3
storage temp.
2-30°C
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