Total Protein Plus Clinical Chemistry Reagent, Elitech

Description

INTENDED USE

ELITech Clinical Systems TOTAL PROTEIN PLUS is an in vitro diagnostic reagent intended for the quantitative determination of total protein in human serum and plasma samples on analyzers or semi-automatic analyzers.

The standard is intended for the calibration of the reagent.

These in vitro diagnostic devices are for professional use only.

CLINICAL SIGNIFICANCE

Plasma proteins are mainly albumin and globulins. Most plasma proteins are synthesized by the liver, except immunoglobulins.

Many factors can modify proteinemia. Increase of the plasmatic volume (salt retention, hyperhydration) or its reduction (dehydration) induce mild hypoproteinemia or mild hyperproteinemia, respectively.

For a normal plasmatic volume, hypoproteinemia can occur in severe protein insufficiencies (malabsorption, maldigestion, dietary insufficiency), or renal (increased protein loss) and hepatic diseases (impaired protein synthesis). Hyperproteinemia can reveal hyperimmu- noglobulinemia (multiple myeloma, infection).

In practice, total proteins measurement is mostly indi- cated to help diagnose liver and kidney disorders, or to determine nutritional status.